Uses of inorganic chemistry in medicine pdf

Biomedical uses of lithium Nicholas J. Buy chapter. Gold complexes with anti-arthritic, anti-tumour and anti-HIV activity C. Frank Shaw III. Nitric oxide in physiology and medicine Anthony R. Butler and Peter S. Therapeutic aspects of manganese II -based superoxide dismutase mimics H. Weiss and Dennis P. Authors: Gray Bertini, Harry B. Stiefel, Professor Edward Stiefel.

Part A. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Royal Society of Chemistry , 31 Oct - Medical - pages. Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine.

Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging.

The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses.

This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.

Chapter 4 is new to the fourth edition and pulls together the experimental techniques that previously were scattered through the book in themed boxes. The inclusion of a large number of worked examples, self-study exercises and end-of chapter problems in this chapter benefits students and teachers alike, and also ensures that the text can support inorganic practical classes in addition to lecture courses. The practical issues of IR spectroscopy detailed in Chapter 4 complement the group theory approach in Chapter 3.

Changes were made on going from the second to the third edition as a result of the recommendations, and this new edition of Inorganic Chemistry incorporates further revisions e. Accompanying this text is a Solutions Manual written by Catherine E. Housecroft, and there is an accompanying Website with multiple choice questions and rotatable structures based on the graphics in the hard-copy text.

The site can be accessed from www. It is always a pleasure to receive emails from those who read and use Inorganic Chemistry.